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Technological and Medical Implications of Metabolic Control Analysis: - Athel Cornish-Bowden, Maria Luz Cardenas
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Athel Cornish-Bowden, Maria Luz Cardenas:

Technological and Medical Implications of Metabolic Control Analysis: - encadernado, livro de bolso

ISBN: 9780792361886

Two decades have passed since the mechanisms of protein synthesis became well enough understood to permit the genetic modification oforganisms. An impressive amount of new knowledge has e… mais…

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Technological and Medical Implications of Metabolic Control Analysis - Maria Luz Cárdenas
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Maria Luz Cárdenas:

Technological and Medical Implications of Metabolic Control Analysis - encadernado, livro de bolso

2000, ISBN: 0792361881

[EAN: 9780792361886], Neubuch, [SC: 0.0], [PU: Springer Netherlands], BEHAVIOR; BIOCHEMISTRY; BIOTECHNOLOGY; CELL; DRUGDEVELOPMENT; ENZYMES; METABOLISM, Druck auf Anfrage Neuware - Printe… mais…

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Technological and Medical Implications of Metabolic Control Analysis - Maria Luz Cárdenas
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Maria Luz Cárdenas:
Technological and Medical Implications of Metabolic Control Analysis - encadernado, livro de bolso

2000

ISBN: 0792361881

[EAN: 9780792361886], Neubuch, [SC: 0.0], [PU: Springer Netherlands], BEHAVIOR; BIOCHEMISTRY; BIOTECHNOLOGY; CELL; DRUGDEVELOPMENT; ENZYMES; METABOLISM, Druck auf Anfrage Neuware -Two dec… mais…

NEW BOOK. Custos de envio:Versandkostenfrei. (EUR 0.00) AHA-BUCH GmbH, Einbeck, Germany [51283250] [Rating: 5 (von 5)]
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Athel Cornish-Bowden:
Technological and Medical Implications of Metabolic Control Analysis - encadernado, livro de bolso

2000, ISBN: 0792361881

[EAN: 9780792361886], New book, [PU: Springer], This item is printed on demand. New copy - Usually dispatched within 5-9 working days, Books

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Technological and Medical Implications of Metabolic Control Analysis (Nato Science Partnership Subseries: 3) [Hardcover ]
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Technological and Medical Implications of Metabolic Control Analysis (Nato Science Partnership Subseries: 3) [Hardcover ] - encadernado, livro de bolso

2000, ISBN: 0792361881

[EAN: 9780792361886], New book, [PU: Springer], Books

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Technological and Medical Implications of Metabolic Control Analysis

The study of multienzyme systems has advanced considerably during the least decade. The cell is more complicated than classical biochemistry presents it, it contains more structure, and the behaviour of any system of enzymes is more elaborate than can be explained in simple terms. Nevertheless, classical enzymology and metabolism remain central to any modification of the metabolic behaviour of organisms, as attempted by modern biotechnology and drug development techniques. In this cool, objective look at the current state of the art, internationally respected authors draw attention to the drawbacks, problems, and opportunities associated with this exciting field. The areas covered include problems with current practice, the imposition of human objectives on organisms, understanding health and disease, computer modelling, the increasingly complex picture of cell structure, control and regulation of metabolism, and the general contribution metabolic control is making to biochemistry on a broader canvas.

Dados detalhados do livro - Technological and Medical Implications of Metabolic Control Analysis


EAN (ISBN-13): 9780792361886
ISBN (ISBN-10): 0792361881
Livro de capa dura
Ano de publicação: 2000
Editor/Editora: Springer
392 Páginas
Peso: 0,748 kg
Língua: eng/Englisch

Livro na base de dados desde 2008-04-01T23:43:01+01:00 (Lisbon)
Página de detalhes modificada pela última vez em 2023-07-04T01:33:02+01:00 (Lisbon)
Número ISBN/EAN: 0792361881

Número ISBN - Ortografia alternativa:
0-7923-6188-1, 978-0-7923-6188-6
Ortografia alternativa e termos de pesquisa relacionados:
Autor do livro: cornish, bowden, cardenas, luz maria
Título do livro: technological medical implications metabolic control analysis, out control


Dados da editora

Autor: Athel Cornish-Bowden; Maria Luz Cárdenas
Título: NATO Science Partnership Subseries: 3; Technological and Medical Implications of Metabolic Control Analysis
Editora: Springer; Springer Netherland
374 Páginas
Ano de publicação: 2000-02-29
Dordrecht; NL
Língua: Inglês
106,99 € (DE)
109,99 € (AT)
118,00 CHF (CH)
Available
XIV, 374 p. 82 illus.

BB; Hardcover, Softcover / Medizin/Klinische Fächer; Klinische und Innere Medizin; Verstehen; behavior; biochemistry; biotechnology; cell; drug development; enzymes; metabolism; Internal Medicine; Biochemistry; Cancer Biology; Mathematical and Computational Biology; Biochemie; Onkologie; DV-gestützte Biologie/Bioinformatik; BC

1. Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems.- 1. Snapshots of systems: metabolic control analysis and biotechnology in the post-genomic era.- 2. Moiety conservation and flux enhancement.- 3. On the universality of the universal method.- 2. Imposing Discipline: Manipulation of Organisms for Technological Ends.- 4. Life is complicated.- 5. Regulation and redirection of metabolism: incorporating regulatory information influx calculation.- 6. Recent developments in metabolic pathway analysis and their potential implications for biotechnology and medicine.- 7. Quantifying the importance of regulatory loops in homeostatic control mechanisms: hierarchical control of DNA supercoiling.- 8. An integrated approach to theanalysis of the control andregulation of cellular systems.- 3. Understanding Health and Disease: Why Organisms Behave as They Do.- 9. Mechanism of carcinogenesis by polycyclic aromatic hydrocarbons: aneuploidy precedes malignant transformation and occurs in all cancers.- 10. Metabolic control analysis shows how aneuploidy causes cancer.- 11. The control strength of glucokinase in hepatocytes: a predictor of metabolic defects in maturity onset diabetes of the young, type 2.- 12. Metabolic distress associated with impaired control by alternative substrates: two examples taken from purine metabolism.- 13. Regulation of ATP supply in muscle: implications for importance of flux control coefficients and for the genesis of mitochondrial myopathies.- 14. Regulation of energy metabolism in hepatocytes.- 15. Combined NMR experimental and computer-simulation study of 2,3-bisphosphoglycerate metabolism in human erythrocytes.- 4. Taking Aim: Use of Metabolic Models to Identify Drug Targets.- 16. Computational approaches to the study of biochemical pathways and metabolic control.- 17. Using metabolic control analysis to improve the selectivity and effectiveness of drugs against parasitic diseases.- 18. Computer simulation as a tool for studying metabolism and drug design.- 19. Use of metabolic control analysis to design a new strategy for cancer therapy.- 5. Facing Reality: Not Just a Bag of Enzymes.- 20. Implications of cytoarchitectural analysis.- 21. Probing the cell interior with NMR spectroscopy.- 22. Metabolite channelling and protein-protein interactions in the urea synthesis pathway.- 23. Intracellular distribution of glycogen synthase: Another regulatory mechanism of glycogen metabolism?.- 24. Supramolecular organization and substrate channelling in the mammalian translation system.- 25. Analysis of co-localization of glycolytic enzymes in flight muscle and its relation to muscle function in Drosophila.- 6. Thinking About Metabolism: The Relationship Between Control and Regulation.- 26. Metabolic control from the back benches: biochemistry towards biocomplexity.- 27. Physiological consequences of a non-regulated mutant phosphofructokinase in Escherichia coli.- 28. Time-dependent or steady-state control of metabolic systems?.- 29. Multisite modulation in the control of glycolysis: balance of supply and demand?.- 30. Exercising control when control is distributed.- 31. Metabolic control design: implications and applications.- 32. Determining elasticities in situ.- 33. Coordination and homeostasis in the response to multiple signals: role of metabolic cascades.- 34. Putting the cart before the horse: designing a metabolic system in order to understand it.- 35. Predicting the structural design of metabolic pathways: an evolutionary approach.- 36. Glycogen structure: an evolutionary view.- 7. Taking Stock: Control Analysis in the Context of Metabolic Regulation.- 37. From control to regulation: a new prospect for metabolic control analysis.- 38. Metabolic control and metabolons in the millennium.- In memoriam: Paul Srere, 1925-1999.- A. Cornish-Bowden.- Contributors.

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