ISBN: 9780444814487

Pharmacology is the science of the action of drugs on the body and incorporates all aspects, from conception, synthesis and effects of drugs to the eventual use in humans. In the initial … mais…

Pharmacology is the science of the action of drugs on the body and incorporates all aspects, from conception, synthesis and effects of drugs to the eventual use in humans. In the initial stages of conception, animal models and cellular models in vitro are utilized to form a hypothesis about the benefits of a drug before clinical trials. This next stage of clinical pharmacology is pivotal as it will validate what was previously conjecture, but the risks taken must be more limited because human beings are involved. The most sophisticated methods of measurement and analysis are utilized at this stage to achieve maximum information with a minimal number of samples. The intention of Human Pharmacology is to examine the state of the art techniques of analysis and measurement of drug concentration in an organism, and of pharmacokinetic methods and their interpretation. Firstly, the work identifies the chemical species of the drug and its metabolites by analysis of biotransformations, and sequential quantification of the active forms of the drug and/or its metabolites in order to evaluate their kinetic parameters.The second part of the book examines the fate of drugs in the body, different ways of interpreting and using pharmacokinetic data and bed-side adjustment of drug dosage regimens. Achievement of results however, must be obtained under rigorously controlled conditions according to stringent internationally recognized criteria. A special chapter is devoted to good laboratory practices. This book is intended for non-specialists or students meaning to follow a career in pharmacology, but it will also prove to be of interest to the specialist in practice having been written by recognized specialists in many fields. Media > Book, [PU: North-Holland]<

1991, ISBN: 0444814485

[EAN: 9780444814487], [SC: 0.0], [PU: Elsevier Science Ltd], Befriedigend/Good: Durchschnittlich erhaltenes Buch bzw. Schutzumschlag mit Gebrauchsspuren, aber vollständigen Seiten. / Desc… mais…

[EAN: 9780444814487], [SC: 0.0], [PU: Elsevier Science Ltd], Befriedigend/Good: Durchschnittlich erhaltenes Buch bzw. Schutzumschlag mit Gebrauchsspuren, aber vollständigen Seiten. / Describes the average WORN book or dust jacket that has all the pages present., Books<